Molecular Imaging of Apolipoprotein B-100 in Human Coronary Plaques by Color Fluorescent Angioscopy and Microscopy

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منابع مشابه

Molecular imaging of apolipoprotein B-100 in human coronary plaques by color fluorescent angioscopy and microscopy.

Apolipoprotein B-100 (ApoB-100) is an important risk factor for coronary artery disease. However, its localization in human coronary plaques is not well understood. The present study was performed to visualize ApoB-100 in human coronary artery wall. Deposition of native ApoB-100 in excised human coronary plaques and normal segments classified by conventional angioscopy was investigated by color...

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Molecular Imaging of Low-density Lipoprotein in Human Coronary Plaques by Color Fluorescent Angioscopy and Microscopy

OBJECTIVES Low-density lipoprotein (LDL) is an important risk factor for coronary artery disease. However, its localization in human coronary plaques is not well understood. The present study was performed to visualize LDL in human coronary artery wall. METHODS (1) The fluorescence characteristic of LDL was investigated by color fluorescent microscopy (CFM) with excitation at 470-nm and emiss...

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Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy

It is generally believed that the coronary plaques with lipid-laden thin fibrous cap and a large lipid core beneath are vulnerable and imaging methods such as intravascular ultrasonography1, optical coherence tomography2, and angioscopy3-5 are clinically employed to detect this type of plaques. However, the coronary plaques that have a thin cap composed of tight calcium layers are frequently ob...

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Detection of vulnerable coronary plaques by color fluorescent angioscopy.

OBJECTIVES This study was carried out to detect vulnerable coronary plaques by color fluorescent angioscopy. BACKGROUND Collagen fibers (CFs) mainly provide mechanical support to coronary plaques. Oxidized low-density lipoprotein (Ox-LDL) induces macrophage proliferation, which in turn destroy CFs while accumulating lipids. As such, demonstration of the absence of CFs, deposition of lipids, a...

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Recent Advances in Fluorescent Angioscopy for Molecular Imaging of Human Atherosclerotic Coronary Plaque

PURPOSE OF REVIEW In vivo imaging of the native substances, including lipoproteins, that comprise human atherosclerotic plaques is currently beyond the scope of any available imaging techniques. Color and near-infrared fluorescent angioscopy (CFA and NIRFA, respectively) systems have been recently developed for molecular imaging of lipoproteins within the human coronary arterial wall ex vivo an...

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ژورنال

عنوان ژورنال: International Heart Journal

سال: 2013

ISSN: 1349-2365,1349-3299

DOI: 10.1536/ihj.54.68